High-Fructose Corn Syrup Enhances Intestinal Tumor Growth In Mice
High-fructose corn syrup (HFCS) is a commonly used sweetener in processed foods and beverages. It has been linked to obesity, diabetes, and other health problems. A recent study has found that HFCS can also enhance the growth of intestinal tumors in mice.
The Study
The study, published in the journal Science, was conducted by researchers at Weill Cornell Medicine and New York University School of Medicine. The researchers fed mice with a diet that contained 25% HFCS, which is similar to the amount of HFCS consumed by many Americans. They found that the mice had a higher incidence of intestinal tumors and the tumors grew faster compared to mice that were fed a normal diet.
The study also found that HFCS increased the production of fructose in the intestine, which in turn led to the activation of a key protein that promotes tumor growth. The protein, called interleukin-33 (IL-33), is produced by cells in the intestine and plays a role in the immune response. However, its overproduction has been linked to the development of colon cancer and other types of cancer.
The Implications
The findings of this study have important implications for human health. HFCS is widely used in processed foods and beverages, including soft drinks, cereals, and baked goods. It is often used as a cheaper alternative to sugar, but its effects on health have been a topic of controversy for years.
The new study suggests that HFCS can not only contribute to obesity and other metabolic disorders but also increase the risk of cancer. The researchers note that the effects of HFCS on tumor growth may be mediated by the gut microbiome, which is the community of microbes that live in the intestine. This opens up new avenues for research into the role of diet and the microbiome in cancer development.
What You Can Do
If you are concerned about the health effects of HFCS, there are several steps you can take. Here are some tips:
- Read food labels carefully and avoid products that contain HFCS.
- Choose whole foods that are naturally sweetened, such as fruits, instead of processed foods and beverages.
- Cook your own meals and snacks whenever possible, so you can control the amount of sugar and other ingredients that go into your food.
- Reduce your overall sugar intake by cutting back on sweets, desserts, and sugary drinks.
The Bottom Line
The new study adds to the growing body of evidence linking HFCS to negative health effects. While more research is needed to fully understand the mechanisms behind these effects, it is clear that reducing your intake of HFCS and other added sugars can have a positive impact on your health. By choosing whole foods and cooking your own meals, you can take control of your diet and reduce your risk of obesity, diabetes, and cancer.